The convergence of engineering with medicine is transforming clinical diagnostics and personalized therapeutics via advances in imaging, nano technology, biomaterials, and data science. The global epidemic of a triad of cardio metabolic risk factors; namely, obesity, Type II diabetes, and hyperlipidemia, is deteriorating society’s health and driving up the costs of health care. The Caltech/UCLA integrated Theranostic Engineering to Advance Metabolic medicine (iTEAM) Program is designed to train the next generation of engineers and physical scientists to develop advanced sensing and imaging technologies to enable early diagnosis and intervention to reverse this silent cardio metabolic epidemic.